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Oral tirzepatide has lower bioavailability than the injectable form, so switching to oral may feel like a dose reduction without a structured tapering schedule

This is a clinically relevant finding from a patient safety perspective as this effect minimizes any potential risk of hypotension or syncope

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If you had intolerable side effects on one medication, switching to the other under medical supervision may improve tolerability, since the molecules are different enough to produce different individual responses

It's approved for adults with a BMI 30 kg/m or 27 kg/m with at least one weight-related comorbidity, as an adjunct to reduced-calorie diet and increased physical activity